Product Name |
14.3.3 sigma antibody |
Catalog No |
10R-S101a |
Size |
200 ug |
Concentration |
0.2 mg/ml |
Price |
$ 722.40
|
Synonymns |
Monoclonal 14.3.3 Sigma antibody, Anti-14.3.3 Sigma antibody, 14-3-3 Sigma antibody |
Description |
Mouse monoclonal 14.3.3 Sigma antibody |
Background |
14-3-3 proteins are a family of small, widely expressed, highly conserved cytosolic proteins. 14-3-3 proteins bind to and influence the activities of a diverse group of molecules involved in signal transduction, cell cycle regulation and
apoptosis, including Raf, PKC, Bad, Cbl, and c-Bcr. Interactions between 14-3-3 and target proteins are strongly influenced by the phosphorylation state of 14-3-3 and the target protein. 14-3-3 sigma shares cyclin-Cdk2 binding motifs with different cell cycle regulators, including p107, p130, p21Cip1, p27Kip1, and p57Kip2 and is associated with cyclin-Cdk complexes in vitro and in vivo. |
Immunogen |
14.3.3 Sigma antibody was raised in mouse using recombinant human 14-3-3 sigma protein as the immunogen. |
Host |
Mouse |
Isotype |
IgG1 kappa |
Clone |
1433S01 |
Specificity |
Human |
Cross Reactivity |
To be determined by end-user |
Method of Purification |
14.3.3 Sigma antibody was purified by Protein G chromatography. |
Form & Buffer |
Antibody purified from ascites fluid by protein G chromotography and supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3. |
Storage |
Store at 4 deg C. |
Applications |
IF, IHC-F, IHC-P, IP |
Usage Recommendations |
IHC-F: 2-4 ug/ml, IHC-P: 2-4 ug/ml, IP: 2 ug/ml protein lysate |
Biohazard Information |
This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. |
