Product Name |
ADAM10 antibody |
Catalog No |
70R-11689 |
Size |
100 ug |
Concentration |
500 ug/ml |
Price |
$ 325.00
|
Synonyms |
Polyclonal ADAM10 antibody, anti-ADAM10 antibody, MADM antibody, EC 3.4.24.81 antibody, ADAM 10 antibody, kuz antibody, CD156c antibody, HsT18717 antibody, ADAM-10, CDw156 antibody, ADAM10, ADAM-10 antibody, ADAM 10 |
Description |
Rabbit polyclonal ADAM10 antibody |
Background |
Proinflammatory cytokine tumor necrosis factoralpha contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-alpha, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM, was recently identified to cleave TNF-alpha, notch and its ligand delta. The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM10, kuzbanian, and MADM, respectively. ADAM10 mRNA is expressed in a variety of human and bovine tissues. |
Immunogen |
ADAM10 antibody was raised in Rabbit using synthetic peptide corresponding to residue surrounding amino acid 735 of human ADAM10 as the immunogen. |
Host |
Rabbit |
Isotype |
IgG |
Cross Reactivity |
Human |
Method of Purification |
ADAM10 antibody was purified by affinity chromatography |
Form & Buffer |
Supplied in PBS buffer, pH 7.2, containing 30% glycerol, 1% BSA, 0.02% thimerosal |
Storage |
Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Applications |
WB |
Usage Recommendations |
IF: 2-10 ug/ml, WB: 1-4 ug/ml |
