Product Name |
ATPIF1 protein (His tag) |
Catalog No |
80R-2373 |
Size |
100 ug |
Concentration |
1 mg/ml |
Price |
$ 295.00
|
Synonyms |
IP protein, ATPIF-1 protein, ATPIF 1 protein, ATPIF1, ATPIF-1, ATPIP protein, mitochondrial protein, ATPIF 1, ATPI protein, ATPase inhibitor protein |
Description |
Purified recombinant Human ATPIF1 protein (His tag) |
Background |
ATPase inhibitory factor 1, also known as ATPIF1, binds to the C-terminal region of a beta subunit of the F1-ATPase at low pH values and, via interference of the beta and gamma subunit interaction, ATPIF1 regulates the activity of the F1 (the hydrophilic catalytic core), F0 (the membrane embedded protein channel) ATPase. The overexpression of ATPIF1 in several human carcinomas further supports its participation in oncogenesis and provides insight into the altered metabolism of cancer cells, which includes the reprogramming of energetic metabolism toward glycolysis. Recombinant human ATPIF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. |
Species |
Human |
Residues |
MGSSHHHHHH SSGLVPRGSH MGSHMGSDQS ENVDRGAGSI REAGGAFGKR EQAEEERYFR AQSREQLAAL KKHHEEEIVH HKKEIERLQK EIERHKQKIK MLKHDD |
Molecular Weight |
12.2 kDa |
Tag |
His tag |
Protein Type |
Recombinant |
Expression System |
E.coli |
.
Grade & Purity |
> 95% by SDS-PAGE |
Form & Buffer |
Supplied in liquid form in 20 mM Tris-HCl buffer (pH 8.0) containing 0.2M NaCl, 50% glycerol, 2 mM DTT |
Storage |
Store at 4 deg C for short term storage. Aliquot and store at -20 or -70 deg C for long term storage. Avoid repeated freeze/thaw cycles. |
Applications |
SDS-PAGE |
