Product Name |
CCR7 antibody |
Catalog No |
10R-6507 |
Size |
100 ug |
Concentration |
500 ug/ml |
Price |
$ 255.00
|
Synonyms |
Monoclonal CCR7 antibody, Anti-CCR7 antibody, C-C chemokine receptor type 7 antibody, CCR 7 antibody, CCR7, CCR-7, MIP-3 beta Receptor antibody, EBI-1 antibody, CCR 7, CMKBR7 antibody, CCR-7 antibody, CCR-7 antibody |
Description |
Rat monoclonal CCR7 antibody |
Background |
The 3D12 monoclonal antibody reacts with human CCR7, also known as EBI-1 and CD197. CCR7 is a member of the G-protein-coupled chemokine receptor family with seven membrane-spanning domains and functions as a receptor for 6Ckine/SLC, CCL19 and CCL21. CCR7 has been shown to be internalized via clathrin-coated pits and the majority recycled back to the plasma membrane. CCR7 is expressed on T cells and can be used to distinguish populations of naïve from central and effector memory T cells. CCR7 has been shown to play a role in migration of memory T cells to inflamed tissue. Expression of CCR7 is also found on DC’s. During DC maturation CCR7 expression increases and is thought to be involved in a variety of functions: chemotaxis to the lymph node, cellular architecture, rate of endocytosis, survival and maturation. Expression of CCR7 on the cell surface can be down regulated upon ligand binding. |
Host |
Rat |
Isotype |
IgG2a kappa |
Clone |
3D12 |
Specificity |
Human |
Method of Purification |
CCR7 antibody was purified by affinity chromatography. |
Form & Buffer |
Supplied in aqueous buffer with 0.09% sodium azide, may contain carrier protein/stabilizer. |
Storage |
Store at 2-8 deg C. Do not freeze. Protect from light. |
Applications |
FC, IHC, IP, WB |
Usage Recommendations |
FC: = 0.5 ug/test |
Assay Information |
A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 ul. Cell number should be determined empirically but can range from 105 to 108 cells/test. It is recommended that the antibody be carefully titrated for optimal /formance in the assay of interest. |
