14.3.3 epsilon protein (30R-1108)
Purified recombinant Human 14.3.3 epsilon protein
|Synonyms||FLJ45465 protein, epsilon polypeptide 14 3 3 E protein, 14/3/3 epsilon protein, Tyrosine 3/tryptophan 5 monooxygenase activation protein epsilon polypeptide., MDCR protein, 14 3 3E protein, KCIP1 protein, YWHAE protein, MDS protein, 14.3.3 epsilon, Tyrosine 3-monooxygenase/ tryptophan 5-monooxygenase activation protein protein, 14-3-3 epsilon protein, 14-3-3 epsilon protein, epsilon polypeptide protein, 14/3/3 epsilon, 14-3-3 epsilon, Protein kinase C inhibitor protein1 protein, Mitochondrial import stimulation factor L subunit protein, Tyrosine 3/tryptophan 5 -monooxygenase activation protein protein, KCIP-1 protein, KCIP 1 protein|
Coomassie Blue stained SDS-PAGE of 14.3.3 epsilon protein (30R-1108)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-255 amino acids: MDDREDLVYQ AKLAEQAERY DEMVESMKKV AGMDVELTVE ERNLLSVAYK NVIGARRASW RIISSIEQKE ENKGGEDKLK MIREYRQMVE TELKLICCDI LDVLDKHLIP AANTGESKVF YYKMKGDYHR YLAEFATGND RKEAAENSLV AYKAASDIAM TELPPTHPIR LGLALNFSVF YYEILNSPDR ACRLAKAAFD DAIAELDTLS EESYKDSTLI MQLLRDNLTL WTSDMQGDGE EQNKEALQDV EDENQ|
|Purity||> 95% pure|
|Molecular Weight||29 kDa (255 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 7.5.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon,sigma, zeta, tau and eta that have been identified in mammals. The 14-3-3 epsilon, a subtype of the 14-3-3 family of proteins, was thought to be brain and neuron-specific. It has been shown to interact with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Recombinant human 14-3-3 epsilon was expressed in E. coli and purified by using conventional chromatography techniques.|
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