26S Proteasome P32 Subunit antibody (10R-2411)

Mouse monoclonal 26S Proteasome P32 Subunit antibody

Synonyms Monoclonal 26S Proteasome P32 Subunit antibody, Anti 26S Proteasome P32 Subunit antibody
Specificity Xenopus laevis 26S Proteasome P32 Subunit
Cross Reactivity Mouse, Rat, Kangaroo
Applications IF, WB
Immunogen 26S Proteasome P32 Subunit antibody was raised in mouse using 26S complexes of Xenopus laevis oocytes as the immunogen.

Specifications

Host Mouse
Clone P32 (26S 161
Isotype IgG1
Form & Buffer Supplied in liquid form, contains 0.09% NaN3

Usage & Assay Information

Usage Recommendations WB: 1:1000

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides.

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