26S Proteasome P52 Subunit antibody (10R-2432)

Mouse monoclonal 26S Proteasome P52 Subunit antibody

Synonyms Monoclonal 26S Proteasome P52 Subunit antibody, Anti 26S Proteasome P52 Subunit antibody
Cross Reactivity Rat, Kangaroo Rat
Applications WB
Immunogen 26S Proteasome P52 Subunit antibody was raised in mouse using 26S proteasomes purified from Xenopus laevis ovary as the immunogen.

Specifications

Host Mouse
Clone P52 (26S-17
Isotype IgG1
Form & Buffer Supplied in liquid form, contains 0.09% NaN3

Usage & Assay Information

Usage Recommendations WB: 1:5 - 1:10

Storage & Safety

Storage Store at 2-8 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance In eukaryotic cells, most proteins in the cytosol and nucleus are degraded via the ubiquitin-proteasome pathway. The 26S proteasome is a 2.5-MDa molecular machine built from approximately 31 different subunits, which catalyzes protein degradation. It contains a barrel-shaped proteolytic core complex (the 20S proteasome), capped at one or both ends by 19S regulatory complexes, which recognize ubiquitinated proteins. The regulatory complexes are also implicated in unfolding and translocation of ubiquitinated targets into the interior of the 20S complex, where they are degraded to oligopeptides.

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