8-OHdG antibody (20R-HG001)

Goat polyclonal 8-OHdG antibody

Synonyms Polyclonal 8-OHdG antibody, Anti-8-OHdG antibody, -OHdG -8 antibody, 8-Hydroxyguanosine antibody, -OHdG 8, 8-OHdG, -OHdG -8, -OHdG 8 antibody
Cross Reactivity To be determined by end-user
Applications ELISA, IHC
Immunogen 8-Hydroxyguanosine antibody was raised in goat using 8-Hydroxyguansoine as the immunogen.

Specifications

Host Goat
Form & Buffer Supplied as liquid whole serum without preservative

Usage & Assay Information

Usage Recommendations ELISA: >1:250,000, IHC-P: >1:200

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually leads to several diseases in humans, such as arteriosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer?s disease.

References
Add a Paper

Emmanuelle Jeannot, Igor P. Pogribny, Frederick A. Beland, Ivan Rusyn

Chronic administration of ethanol leads to an increased incidence of hepatocellular adenoma by promoting H-ras-mutated cells

Cancer Letters

Volume: 301 Issue: 2 Page: 161-167 DOI: 10.1016/j.canlet.2010.11.010

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Availability: In stock

Price: $346.50
Size: 250 ul
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