ACY1 antibody (10R-3178)

Mouse monoclonal ACY1 antibody

Synonyms Monoclonal ACY1 antibody, Anti-ACY1 antibody, ACY1D antibody, ACYLASE antibody, Aminoacylase 1 antibody, ACY1, ACY 1, ACY-1, ACY 1 antibody, ACY-1 antibody
Cross Reactivity Human, Dog, Rat, Mouse
Applications FC, IHC, WB
Immunogen ACY1 antibody was raised in mouse using a full length recombinant protein of human ACY1 (NP_000657) produced in HEk293 cell as the immunogen.

Images

Flow Cytometric analysis using ACY1 antibody (10R-3178)

Flow Cytometric analysis of HEK293T cells transfected with either recombinant ACY1 protein (red) or empty vector (blue) stained using ACY1 antibody

Specifications

Host Mouse
Clone 1B12
Isotype IgG1
Method of Purification ACY1 antibody was purified by affinity chromatography.
Form & Buffer Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 500 ug-1 mg/ml

Usage & Assay Information

Usage Recommendations FC: 1:100, IHC: 1:150, WB: 1:200-500

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance ACY1 is a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. Defects in ACY1 are the cause of aminoacylase-1 deficiency (ACY1D). ACY1D results in a metabolic disorder manifesting with encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urin ary excretion of several N-acetylated amino acids.

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Images

  • Flow Cytometric analysis using ACY1 antibody (10R-3178) | Flow Cytometric analysis of HEK293T cells transfected with either recombinant ACY1 protein (red) or empty vector (blue) stained using ACY1 antibody
  • Western Blot analysis using ACY1 antibody (10R-3178) | Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant ACY1 protein (Right) or empty vector (Left) detected with ACY1 antibody
  • Immunohistochemical staining using ACY1 antibody (10R-3178) | Immunohistochemical analysis of ACY1 protein in paraffin embedded Human liver tissue using ACY1 antibody

Availability: In stock

Price: $395.00
Size: 100 ul
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