Adipophilin antibody (20R-AP002)

Guinea Pig polyclonal Adipophilin antibody

Synonyms Polyclonal Adipophilin antibody, Anti-Adipophilin antibody
Specificity Human adipophilin
Cross Reactivity Bovine, dog, human, mouse, rat
Applications IHC-F, IHC-P, WB
Immunogen Adipophilin antibody was raised in guinea pig using a synthetic peptide corresponding to residues 1-29 of the N-terminus of human and murine adipophilin as the immunogen.
Assay Information Adipocytes are negative. Also positively stained are lipid-storing CD 68-positive macrophages.

Specifications

Host Guinea Pig
Purity Whole antiserum
Form & Buffer Supplied as whole antiserum with 0.09% NaN3.

Usage & Assay Information

Usage Recommendations IHC-F: 1:100, IHC-P: 1:100, WB: 1:2,000

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product.

General Information

Biological Significance Adipophilin / ADRP (a member of the PAT family) is a ubiquitous component of lipid droplets. It has been found in milk fat globule membranes and on the surface of lipid droplets in various cultured cell lines (see e.g. Heid et al.; for review see e.g. Targett-Adams et al.); inducible by etomoxir. Enhanced expression of Adipophilin / ADRP is a useful marker for pathologies characterized by increased lipid droplet accumulation. Such diseases include atheroma, steatosis, obesity and certain cases of liposarcoma. It also seems to be a potent marker for atherosclerosis.

References
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Biol Open

PMID: 26276101 DOI: 10.1242/bio.013433

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