AIFM1 antibody (70R-10447)
Affinity purified rabbit polyclonal AIFM1 antibody
|Synonyms||Polyclonal AIFM1 antibody, Anti-AIFM1 antibody, AIFM-1, AIFM1, AIFM 1 antibody, AIFM 1, PDCD8 antibody, AIFM-1 antibody, MGC111425 antibody, apoptosis-inducing factor, AIF antibody, mitochondrion-associated, 1 antibody|
|Cross Reactivity||Human, Mouse, Rat, Dog, Bovine, Zebrafish, Chicken|
|Immunogen||AIFM1 antibody was raised in rabbit using the middle region of AIFM1 as the immunogen|
|Assay Information||AIFM1 Blocking Peptide, catalog no. 33R-9594, is also available for use as a blocking control in assays to test for specificity of this AIFM1 antibody|
Western Blot analysis using AIFM1 antibody (70R-10447)
Western Blot showing AIFM1 antibody used at a concentration of 1-2 ug/ml to detect its target protein.
|Form & Buffer||Lyophilized powder. Add 50 ul of distilled water. Final antibody concentration is 1 mg/ml in PBS buffer.|
Usage & Assay Information
|Usage Recommendations||WB: 0.2-1 ug/ml|
Storage & Safety
|Storage||Store at 4 deg C, following reconstitution, aliquot and store at -20 deg C. Avoid repeated freeze-thaw cycles.|
|Biological Significance||AIFM1 is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it effects chromosome condensation and fragmentation. In addition, this protein induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Several alternative transcripts encoding different isoforms have been identified for this gene.|
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