AKR1A1 antibody (10R-3257)

Mouse monoclonal AKR1A1 antibody

Synonyms Monoclonal AKR1A1 antibody, Anti-AKR1A1 antibody, ALDR1 antibody, ALR antibody, ARM antibody, DD3 antibody, Alcohol dehydrogenase [NADP+] antibody, Alcohol dehydrogenase antibody, Aldehyde reductase antibody, aldo-keto reductase family 1 member A1 antibody, AKR1A1, AKRA 1, AKRA-1, AKRA 1 antibody, AKRA-1 antibody
Cross Reactivity Human
Applications FC, IHC, WB
Immunogen AKR1A1 antibody was raised in mouse using a full length recombinant protein of human AKR1A1 (NP_006057) produced in HEK293T cells, as the immunogen.

Images

Flow Cytometric analysis using AKR1A1 antibody (10R-3257)

Flow Cytometric analysis of Hela cells using AKR1A1 antibody (Red), compared to a nonspecific negative control antibody (Blue).

Specifications

Host Mouse
Clone 8 E12
Isotype IgG1
Method of Purification AKR1A1 antibody was purified by affinity chromatography.
Form & Buffer Supplied in PBS buffer, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 500 ug-1 mg/ml

Usage & Assay Information

Usage Recommendations FC: 1:100, IHC: 1:50, WB: 1:2000

Storage & Safety

Storage Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance AKR1A1 is a member of the aldo/keto reductase superfamily and catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. This protein is closely related (65% identity) to aldose reductase, an enzyme involved in the pathogenesis of some diabetic and galactosemic complications. It plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

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Images

  • Flow Cytometric analysis using AKR1A1 antibody (10R-3257) | Flow Cytometric analysis of Hela cells using AKR1A1 antibody (Red), compared to a nonspecific negative control antibody (Blue).
  • Western Blot analysis using AKR1A1 antibody (10R-3257) | Western Blot analysis of HEK293T cell lysates (5 ug) transfected with either recombinant AKR1A1 protein (Right) or empty vector (Left) detected with AKR1A1 antibody
  • Immunohistochemical staining using AKR1A1 antibody (10R-3257) | Immunohistochemical analysis of AKR1A1 protein in paraffin embedded Human liver tissue using AKR1A1 antibody

Availability: In stock

Price: $395.00
Size: 100 ul
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