AKR1C1 antibody (10R-1776)

Mouse monoclonal AKR1C1 antibody

Synonyms Monoclonal AKR1C1 antibody, Anti-AKR1C1 antibody, AKR1C1, 2 diol dehydrogenase antibody, Chlordecone reductase homolog HAKRC antibody, HAKRC antibody, DDH antibody, 2ALPHAHSD antibody, AKRC 1, Aldo-keto reductase family 1 antibody, AKRC-1 antibody, C9 antibody, 2 dihydrobenzene 1 antibody, member C1 20 alpha (3 alpha) hydroxysteroid dehydrogenase antibody, Dihydrodiol dehydrogenase 1/2 antibody, MBAB antibody, AKRC-1, High affinity hepatic bile acid-binding protein antibody, AKRC 1 antibody, DDH1 antibody, 20-alpha-HSD antibody, Dihydrodiol dehydrogenase 1 antibody, Type II 3 alpha hydroxysteroid dehydrogenase antibody, Chlordecone reductase homolog antibody, Aldo keto reductase family 1 member C1 antibody, Hepatic dihydrodiol dehydrogenase antibody, HBAB antibody, DD1 antibody, H37 antibody, AK1C1 antibody, 20 alpha hydroxysteroid dehydrogenase antibody, DD1/DD2 antibody, Trans-1 antibody
Cross Reactivity Human
Applications ELISA, WB
Immunogen AKR1C1 antibody was raised in mouse using recombinant human AKR1C1 (1-323aa) purified from E. coli as the immunogen.

Images

Western blot analysis using AKR1C1 antibody (10R-1776)

Figure is annotated with cell line lysates which were probed by the antibody

Specifications

Host Mouse
Clone AT6D10
Isotype IgG1,k
Source Anti-human AKR1C1 antibody, clone AT6D10, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human AKR1C1 protein.
Method of Purification By protein-G affinity chromatography
Form & Buffer Liquid. In Phosphate-Buffered Saline (pH 7.4) with 0.1% Sodium Azide
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Each investigation should be titrated by the reagent to obtain optimal results. Recommended dilution range for Western blot analysis is 1:500 ~ 1:5000. Recommended starting dilution is 1:1000

Storage & Safety

Storage Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.

General Information

Biological Significance The human aldo-keto reductases 1C1 and 1C3 (AKR1C1 and AKR1C3) have major roles in pre receptor regulation of progesterone action. They can both convert progesterone to the less potent efficiencies. AKR1C1 and AKR1C3 also act as 3-ketosteroid reductase, and as such they can convert the most potent androgen 5alpha-DHT into 3beta-andorstandiol, which is an estrogen receptor beta ligand, and into the inactive androgen 3alpha-androstnionl, respectively.

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Images

  • Western blot analysis using AKR1C1 antibody (10R-1776) | Figure is annotated with cell line lysates which were probed by the antibody

Availability: In stock

Price: $270.00
Size: 100 ul
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