Alpha 1 Antichymotrypsin protein (His tag) (80R-1217)
Purified recombinant Human Alpha 1 Antichymotrypsin protein
|Synonyms||Serpin peptidase inhibitor clade A (alpha 1 antiproteinase antitrypsin) member 3., member 3 Cell growth inhibiting gene 24/25 protein protein, Alpha 1 Antichymotrypsin, Antichymotrypsin protein, Serine (or cysteine) proteinase inhibitor clade A (alpha 1 antiproteinase protein, antitrypsin) member 3 protein, MGC88254 protein, SERPINA3 protein, GIG24 protein, Growth inhibiting protein 24 protein, GIG25 protein, clade A protein, Serpin peptidase inhibitor protein, alpha-1-Antichymotrypsin, Serine (or cysteine) proteinase inhibitor clade A member 3 protein, Growth inhibiting protein 25 protein, Serine proteinase inhibitor clade A member 3 protein, AACT protein, alpha-1-Antichymotrypsin protein, ACT protein|
Coomassie Blue stained SDS-PAGE of Alpha1antichymotrypsin protein (His tag) (80R-1217)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||24-423 amino acids: MGSSHHHHHH SSGLVPRGSH MHPNSPLDEE NLTQENQDRG THVDLGLASA NVDFAFSLYK QLVLKAPDKN VIFSPLSIST ALAFLSLGAH NTTLTEILKG LKFNLTETSE AEIHQSFQHL LRTLNQSSDE LQLSMGNAMF VKEQLSLLDR FTEDAKRLYG SEAFATDFQD SAAAKKLIND YVKNGTRGKI TDLIKDLDSQ TMMVLVNYIF FKAKWEMPFD PQDTHQSRFY LSKKKWVMVP MMSLHHLTIP YFRDEELSCT VVELKYTGNA SALFILPDQD KMEEVEAMLL PETLKRWRDS LEFREIGELY LPKFSISRDY NLNDILLQLG IEEAFTSKAD LSGITGARNL AVSQVVHKAV LDVFEEGTEA SAATAVKITL LSALVETRTI VRFNRPFLMI IVPTDTQNIF FMSKVTNPKQ A|
|Purity||> 95% pure|
|Molecular Weight||47.6 kDa (421aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, and 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Alpha-1-antichymotrypsin is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. Recombinant alpha-1-antichymotrypsin protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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