alpha 1 Antitrypsin antibody (20R-AR009)
Rabbit polyclonal alpha 1 Antitrypsin antibody
|Synonyms||Polyclonal alpha 1 Antitrypsin antibody, Anti-alpha 1 Antitrypsin antibody, A1AT antibody, alpha 1 antibody, alpha-1 Antitrypsin antibody, A1-AT antibody|
|Cross Reactivity||Baboon, horse, mink, monkey|
|Immunogen||Alpha 1 antitrypsin antibody was raised in rabbit using purified human serum Alpha-1-AT as the immunogen.|
Immunohistochemical staining using alpha 1 Antitrypsin antibody (20R-AR009)
Formalin-fixed, paraffin-embedded human tonsil stained with a-1-Antitrypsin (AAT) antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of endothelial cells.
|Form & Buffer||Purified antibody fraction from rabbit serum supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.|
Usage & Assay Information
|Usage Recommendations||IHC-F: 1:100-1:200, IHC-P: 1:100-1:200|
Storage & Safety
|Storage||Store at 4 deg C.|
|Biohazard Information||This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.|
|Biological Significance||Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.|
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