alpha 1 Antitrypsin antibody (20R-AR009)

Rabbit polyclonal alpha 1 Antitrypsin antibody

Synonyms Polyclonal alpha 1 Antitrypsin antibody, Anti-alpha 1 Antitrypsin antibody, A1AT antibody, alpha 1 antibody, alpha-1 Antitrypsin antibody, A1-AT antibody
Specificity Human
Cross Reactivity Baboon, horse, mink, monkey
Applications IHC-F, IHC-P
Immunogen Alpha 1 antitrypsin antibody was raised in rabbit using purified human serum Alpha-1-AT as the immunogen.

Images

Immunohistochemical staining using alpha 1 Antitrypsin antibody (20R-AR009)

Formalin-fixed, paraffin-embedded human tonsil stained with a-1-Antitrypsin (AAT) antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of endothelial cells.

Specifications

Host Rabbit
Form & Buffer Purified antibody fraction from rabbit serum supplied in 10mM PBS, pH 7.4, with 0.2% BSA and 0.09% NaN3.

Usage & Assay Information

Usage Recommendations IHC-F: 1:100-1:200, IHC-P: 1:100-1:200

Storage & Safety

Storage Store at 4 deg C.
Biohazard Information This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling.

General Information

Biological Significance Alpha-1-antitrypsin (alpha-1-AT) exists in a number of genetic variants. MM variant is the most common. Alpha-1-AT is synthesized in the liver and it acts as an inhibitor of proteases such as trypsin, elastase, chymotrypsin, collagenase, leucocytic proteases, plasmin, and thrombin, which may be released during inflammatory reactions in the lung. In the absence of alpha-1-AT, these enzymes are not inhibited and they may digest pulmonary parenchyma. Alpha-1-AT deficiency is associated with chronic obstructive lung disease (emphysema) and less frequently with hepatic cirrhosis in infants and respiratory distress of the newborn. Increase in alpha-1-AT occurs as an acute phase response to tissue necrosis and inflammation. Serum level of alpha-1-AT is elevated in rheumatoid arthritis, bacterial infections, vasculitis, and carcinomatosis.

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Images

  • Immunohistochemical staining using alpha 1 Antitrypsin antibody (20R-AR009) | Formalin-fixed, paraffin-embedded human tonsil stained with a-1-Antitrypsin (AAT) antibody using peroxidase-conjugate and AEC chromogen. Note cytoplasmic staining of endothelial cells.

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Price: $484.00
Size: 1 ml
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