alpha Actin antibody (smooth muscle) (10R-7938)

Mouse monoclonal alpha Actin antibody (smooth muscle)

Synonyms Monoclonal alpha Actin antibody, Anti-alpha Actin antibody, alpha Actin 1 antibody, alpha Actin, alpha Actin
Specificity alpha Actin reacts exclusively with alpha-smooth muscle actin which is typical for vascular and visceral smooth muscle cells, but which is also present in myofibroblasts. The epitope that is recognized by alpha-SM1 is Ac-EEED
Cross Reactivity Chicken, Goat, Monkey, Quail, Rat, Sheep, Swine, Xenopus
Applications IHC, IHC-F, IHC-P, WB
Immunogen alpha Actin antibody (smooth muscle) was raised in Mouse using a peptide comprising the first 10 amino acids of alpha-smooth muscle actin with an acetylated N-terminus coupled to keyhole limpet hemocyanin via the C-terminal cysteine (Ac-EEEDSTALVC) as t

Specifications

Host Mouse
Clone 1A4
Isotype IgG2a
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations IHC: 1:10-1:100, WB: 1:100-1:500

General Information

Biological Significance Among the six actin isoforms described in mammals, two are found in virtually all cells (beta- and gamma-cytoplasmic), two are detected in smooth muscle cells (alpha- and gamma-smooth muscle) and two are present in striated muscles, one predominantly in skeletal (alpha-skeletal) and one in cardiac (alpha-cardiac) muscle cells. These actin isoforms differ slightly in their N-terminus, but the sequence of each of these actins is highly conserved in higher vertebrates. Alpha-smooth muscle actin is abundant in vascular and visceral smooth muscle cells. In addition, it has also been shown to appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases.

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Availability: In stock

Price: $395.00
Size: 50 ug
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