alpha Synuclein E46K protein (30R-1012)
Purified recombinant Human alpha Synuclein E46K protein
|Synonyms||Parkinson disease familial 1 protein, PD1 protein, Non-A4 component of amyloid precursor protein, alpha synuclein E46k protein, PD 1 protein, Alpha synuclein protein, alphaSYN protein, Non A beta component of AD amyloid protein, Non A4 component of amyloid precursor protein, Synuclein alpha protein, MGC110988 protein, alpha-synuclein e46k protein, MGC64356 protein, NACP protein, Non-A-beta component of alzheimers disease amyloid protein, precursor of PARK 1 protein, alpha-Synuclein protein, Non-A beta component of AD amyloid protein, MGC105443 protein, SNCA protein, MGC127560 protein, Alpha-synuclein isoform NACP140 protein, PARK4 protein, PARK1 protein, , PARK 4 protein|
Coomassie Blue stained SDS-PAGE of alpha Synuclein E46K protein (30R-1012)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKKGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA|
|Purity||> 95% pure|
|Molecular Weight||14.4 kDa (140 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)|
|Form & Buffer||Supplied as a liquid in 20 mM Tris-HCl buffer, pH 7.5, containing 0.1 M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Alpha-synuclein E46K is a mutant form of alpha-synuclein which is changed at position 46 from glutamate(E) to lysine(K). Recent studies have shown that this mutant(E46K) of alpha-synuclein causes Parkinson and Lewy Body dementia(DLB). Alpha-synuclein E46K was overexpressed in E. coli and purified to apparent homogeneity by using conventional column chromatography techniques.|
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