alpha Synuclein protein (30R-1001)

Purified recombinant Human alpha Synuclein protein

Synonyms alphaSYN protein, SNCA protein, Non-A beta component of AD amyloid protein, PARK1 protein, , Non-A4 component of amyloid precursor protein, Synuclein alpha protein, MGC64356 protein, PARK 4 protein, Non-A-beta component of alzheimers disease amyloid protein, MGC127560 protein, Non A beta component of AD amyloid protein, Parkinson disease familial 1 protein, Non A4 component of amyloid precursor protein, alpha-Synuclein protein, MGC110988 protein, NACP protein, Alpha-synuclein isoform NACP140 protein, PD1 protein, precursor of PARK 1 protein, MGC105443 protein, Alpha synuclein protein, PD 1 protein, PARK4 protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of alpha Synuclein protein (30R-1001)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Expression System E.coli
Purity > 95% pure
Molecular Weight 14.4 kDa (140 aa), confirmed by MALDI-TOF. (Molecular weight on SDS-PAGE will appear higher)
Form & Buffer Lyophilized from a 0.2 um filtered in 20 mM Tris-HCl buffer, pH 7.5 , containing 100mM NaCl, and 1mM MgCl2. Reconstitute in sterile distilled water at a concentration of 1 mg/ml or less.
Concentration 1 mg/ml

Storage & Safety

Storage The product is shipped at ambient temperature. Upon receipt, store it immediately at 4 deg C in the short term (1 month). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freeze/thaw cycles.
Endotoxin Levels < 1.0 EU per ug of protein (determined by LAL method)

General Information

Biological Significance alpha-Synuclein (amino acids 1-140), an acidic neuronal protein of 140 amino acids, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. alpha-synuclein has been suggested to be implicated in the pathogenesis of Parkinson?s disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).

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Images

  • Coomassie Blue stained SDS-PAGE of alpha Synuclein protein (30R-1001) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $250.00
Size: 100 ug
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