Ankyrin 1 antibody (70R-1856)

Rabbit polyclonal Ankyrin 1 antibody raised against the C terminal of ANK1

Synonyms Polyclonal Ankyrin 1 antibody, Anti-Ankyrin 1 antibody, SPH2 antibody, ANK1 antibody, SPH1 antibody, Ankyrin 1 Erythrocytic antibody
Specificity Ankyrin 1 antibody was raised against the C terminal of ANK1
Cross Reactivity Human, Mouse, Rat, Dog
Applications IHC, WB
Immunogen Ankyrin 1 antibody was raised using the C terminal of ANK1 corresponding to a region with amino acids VVRQIDLSSADAAQEHEEVELRGSGLQPDLIEGRKGAQIVKRASLKRGKQ
Assay Information Ankyrin 1 Blocking Peptide, catalog no. 33R-9893, is also available for use as a blocking control in assays to test for specificity of this Ankyrin 1 antibody

Images

Western Blot analysis using Ankyrin 1 antibody (70R-1856)

Ankyrin 1 antibody (70R-1856) used at 1.25 ug/ml to detect target protein.

Specifications

Host Rabbit
Method of Purification Total IgG Protein A purified
Molecular Weight 17 kDa (MW of target protein)
Form & Buffer Lyophilized powder. Add 100ul distilled water for a 1mg/ml concentration of ANK1 antibody in PBS
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations WB: 1.25 ug/ml; IHC: 4-8 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for short periods. For longer periods of storage, store at -20 deg C. Avoid repeat freeze-thaw cycles.

General Information

Biological Significance Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact and the maintenance of specialized membrane domains. Ankyrin 1, the prototype of this family, was first discovered in the erythrocytes, but since has also been found in brain and muscles. Mutations in erythrocytic ankyrin 1 have been associated in approximately half of all patients with hereditary spherocytosis. Complex patterns of alternative splicing in the regulatory domain, giving rise to different isoforms of ankyrin 1 have been described, however, the precise functions of the various isoforms are not known.

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Images

  • Western Blot analysis using Ankyrin 1 antibody (70R-1856) | Ankyrin 1 antibody (70R-1856) used at 1.25 ug/ml to detect target protein.
  • Immunohistochemical staining using Ankyrin 1 antibody (70R-1856) | Ankyrin 1 antibody was used for immunohistochemistry at a concentration of 4-8 ug/ml to stain Alveolar cells (arrows) in Human Lung. Magnification is at 400X

Availability: In stock

Price: $275.00
Size: 100 ug
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