Beta Catenin antibody

beta Catenin antibodies are commonly used to study the control of cellular proliferation or cell death in several types of cancer. beta Catenin was initially associated with the cytoplasmic region of E-cadherin, but has now been shown to perform two important but apparently unrelated functions: it has a crucial role in cell-cell adhesion in addition as well as a signal transduction function as part of the Wnt/wg signalling pathway.

Wnt signaling results in the accumulation of beta-catenin during development as well as transcriptional activation of development related genes. For this reason abnormal beta-catenin signaling has been implicated in several malignancies including colon cancer, ovarian cancer, endometrial cancer, melanoma, hepatocellular carcinoma and prostate cancer. beta Catenin mutations have been identified as the main cause in several of these conditions, suggesting an important role for this protein in the control of cellular proliferation or cell death.

With its dual function as a regulator of growth and development and cell signalling as well as its role as an oncogene and possible therapeutic target in cancer, beta catenin continues to receive significant attention from researchers in a variety of fields. Fitzgerald Industries supplies a wide range of beta catenin antibodies in monoclonal and polyclonal formats from a variety of host species as well as gamma catenin, delta catenin and alpha catenin antibodies.

Some of our most popular beta catenin antibodies include:

This rabbit polyclonal B-Catenin antibody is suitable for both IHC-F and IHC-P and Western blotting. It is an affinity purified beta Catenin antibody specific for C-terminal of beta Catenin, which is conserved in human, rat and rabbit.

Immunohistochemistry of paraffin-embedded section of Human Mammary Cancer Tissue
Immunohistochemistry of paraffin-embedded section of Human
Mammary Cancer Tissue

The monoclonal beta Catenin antibody (clone 15B8) reacts with both human and mouse beta Catenin and is rated for use in Flow Cytometry as well as Western blotting and Immunocytochemistry.

This rabbit polyclonal beta Catenin antibody is highly purified by affinity chromatography and provides excellent results in Western blot procedures for human, mouse, and rat. The antibody was raised using a peptide of amino acids 652~656 (A-T-Y-A-A).