Tau antiodies are commonly used for studying Alzheimer's disease pathology is a highly soluble microtubule-associated protein commonly found in neurons. Tau functions in the promotion of microtubule assembly and stability and is thought to be involved in the maintenance of neuronal polarity.
Tau aggregation occurs in neurodegenerative diseases including Alzheimer’s disease and many other disorders and defects in Tau protein and subsequent failures in microtubule assembly are common features of these diseases. Defects in Tau expression and phosphorylation give rise to neurofibrillary tangles, a major hallmark of Alzheimer’s disease.
With the global population aging at an unprecedented rate and life expectancy rising globally, neurological diseases are also on the rise as is research in new therapies to mitigate or reverse their effects. Fitzgerald Industries supplies a wide range of neuroscience related antibodies including monoclonal and polyclonal Tau antibodies ideally suited for use in neurological research as well as in the development of diagnostic techniques.
Some of our most popular Tau antibodies include:
Tau antibody - This mouse monoclonal Tau antibody is specific for bovine Tau proteins and is highly rated for use in Immunofluorescence, Immunoprecipitation and Western blotting.
Tau antibody - This purified rabbit polyclonal Tau antibody is recommended for use in Western blot and has reported excellent results in immunohistochemical staining as shown below. It reacts with Human, Mouse, and Rat Tau protein.
|Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer's Disease using Tau (Phospho-Thr205) antibody|
phospho Tau antibody - This goat polyclonal Tau antibody is specific for phosphorylated Tau (Ser404) and is validated for use in Immunohistochemistry, Immunoprecipitation and Western blot. It reacts with phosphorylated Tau in Human, Mouse, Rat.
Check out some more of our neurodegenerative disease antibodies.