APEX1 antibody (10R-1584)

Mouse monoclonal APEX1 antibody

Synonyms Monoclonal APEX1 antibody, Anti-APEX1 antibody, APEN antibody, APEX1, APEX 1 antibody, APX antibody, REF-1 antibody, APE1 antibody, APE antibody, APE-1 antibody, REF1 antibody, HAP1 antibody, APEX 1, Apurinic-apyrimidinic endonuclease 1 antibody, APEX-1 antibody, APEX antibody, APEX-1
Specificity Human APEX1
Cross Reactivity Human, Mouse, Rat. Other species not studied
Applications Dot Blot, WB
Immunogen APEX1 antibody was raised in mouse using recombinant Human Apex Nuclease (Multifunctional Dna Repair Enzyme) 1(Apex1)

Images

Western Blot analysis of immunized recombinant protein using APEX1 antibody (10R-1584)

Specifications

Host Mouse
Clone 2027C2a
Isotype IgG1
Method of Purification APEX1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer APEX1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-2 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes the major AP endonuclease in human cells. Splice variants have been found for this gene; all encode the same protein.

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Images

  • Western Blot analysis of immunized recombinant protein using APEX1 antibody (10R-1584)

Availability: In stock

Price: $190.00
Size: 50 ug
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