APP protein (His tag) (80R-2240)
Purified recombinant Human APP Protein (His tag)
|Synonyms||AD1 protein, ABETA protein, CVAP protein, CTF gamma protein, ABPP protein, PN2 protein, APPI protein, AAA protein, Amyloid beta A4 protein protein|
Coomassie Blue stained SDS-PAGE of APP protein (His tag) (80R-2240)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSLEVP TDGNAGLLAE PQIAMFCGRL NMHMNVQNGK WDSDPSGTKT CIDTKEGILQ YCQEVYPELQ ITNVVEANQP VTIQNWCKRG RKQCKTHPHF VIPYRCLVGE FVSDALLVPD KCKFLHQERM DVCETHLHWH TVAKETCSEK STNLHDYGML LPCGIDKFRG VEFVCCPLAE ESDNVDSADA EEDDSDVWWG GADTDYADGS EDKVVEVAEE EEVAEVEEEE ADDDEDDEDG DEVEEEAEEP YEEATERTTS IATTTTTTTE SVEEVVRE|
|Purity||> 85% pure|
|Molecular Weight||34.7 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer, pH 8.0 containing 20% glycerol, 0.1M NaCl, 1mM DTT.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||APP is a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease.|
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