Aprataxin protein (His tag) (80R-1256)
Purified recombinant Human Aprataxin protein
|Synonyms||EOAHA protein, FHA HIT protein, Aprataxin homolog protein, AOA1 protein, EAOH protein, AOA protein, Forkhead associated domain histidine triad like protein, Ataxia1 early onset with hypoalbuminemia protein, Forkhead associated domain histidine triad like protein., Ataxia 1 early onset with hypoalbuminemia protein, AXA1 protein, APTX protein, AOA 1 protein, FLJ20157 protein, MGC1072 protein, AXA 1 protein|
Coomassie Blue stained SDS-PAGE of Aprataxin protein (His tag) (80R-1256)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-168 amino acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWAGSMQD PKMQVYKDEQ VVVIKDKYPK ARYHWLVLPW TSISSLKAVA REHLELLKHM HTVGEKVIVD FAGSSKLRFR LGYHAIPSMS HVHLHVISQD FDSPCLKNKK HWNSFNTEYF LESQAVIEMV QEAGRVTVRD GMPELLKLPL RCHECQQLLP SIPQLKEHLR KHWTQ|
|Purity||> 95% pure|
|Molecular Weight||23.9 kDa (205aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 7.5, containing 20% glycerol, 100mM NaCl and 0.1mM PMSF.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Aprataxin is a member of the histidine triad (HIT) superfamily, some of which have nucleotide-binding and diadenosine polyphosphate hydrolase activities. Aprataxin may play a role in single-stranded DNA repair. Mutations in the gene have been associated with neurological disorder known as ataxia oculomotor apraxia-1. Recombinant Aprataxin protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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