AR antibody (10R-2031)
Mouse monoclonal AR antibody
|Synonyms||Monoclonal AR antibody, Anti-AR antibody, Androgen Receptor antibody|
|Immunogen||AR antibody was raised in Mouse using a purified recombinant fragment of AR(aa689-919) expressed in E. coli as the immunogen.|
Western Blot analysis using AR antibody (10R-2031)
Western Blot showing AR antibody used against truncated Trx-AR recombinant protein (1).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||AR functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.|
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