ARPP19 protein (His tag) (80R-3582)
Purified recombinant ARPP19 protein (His tag)
|Synonyms||ARPP-16 protein, ARPP-19 protein, ARPP16 protein, ENSAL protein, ARPP 19 protein, ARPP-19 protein|
Coomassie blue stained SDS-PAGE of ARPP19 protein (His tag) (80R-3582)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-112 aa: MGSSHHHHHH SSGLVPRGSH MGSMSAEVPE AASAEEQKEM EDKVTSPEKA EEAKLKARYP HLGQKPGGSD FLRKRLQKGQ KYFDSGDYNM AKAKMKNKQL PTAAPDKTEV TGDHIPTPQD LPQRKPSLVA SKLAG|
|Purity||> 90% pure|
|Method of Purification||ARPP19 protein was purified by using conventional chromatography techniques|
|Molecular Weight||14.7 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||cAMP-regulated phosphoprotein 19, also known as ARPP19, is protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase. This protein may indirectly enhance GAP-43 expression.|
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