ASXL1 antibody (10R-1309)

Mouse monoclonal ASXL1 antibody

Synonyms Monoclonal ASXL1 antibody, Anti-ASXL1 antibody, ASXL 1, MGC71111 antibody, KIAA0978 antibody, ASXL 1 antibody, Additional sex combs like 1 antibody, MGC117280 antibody, ASXL-1, ASXL1, ASXL-1 antibody
Specificity Human ASXL1
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen ASXL1 antibody was raised in mouse using recombinant Human Additional Sex Combs Like 1 (Drosophila) (Asxl1)

Images

Western Blot analysis of immunized recombinant protein using ASXL1 antibody (10R-1309)

Left: ASXL1 staining. Right: Coomassie Blue staining of immunized recombinant protein.

Specifications

Host Mouse
Clone 2049C2a
Isotype IgG1
Method of Purification ASXL1 antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer ASXL1 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

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Images

  • Western Blot analysis of immunized recombinant protein using ASXL1 antibody (10R-1309) | Left: ASXL1 staining. Right: Coomassie Blue staining of immunized recombinant protein.

Availability: In stock

Price: $190.00
Size: 50 ug
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