ATF7IP antibody (10R-1315)

Mouse monoclonal ATF7IP antibody

Synonyms Monoclonal ATF7IP antibody, Anti-ATF7IP antibody, FLJ10688 antibody, ATFIP-7, ATF7IP, ATFIP 7, p621 antibody, FLJ10139 antibody, ATFIP-7 antibody, ATFIP 7 antibody, Activating transcription factor 7 interacting protein antibody, MCAF antibody
Specificity Human ATF7IP
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen ATF7IP antibody was raised in mouse using recombinant Human Activating Transcription Factor 7 Interacting Protein (Atf7Ip)

Images

Western Blot analysis of immunized recombinant protein using ATF7IP antibody (10R-1315)

Left: ATF7IP staining. Right: Coomassie Blue staining of immunized recombinant protein.

Specifications

Host Mouse
Clone 2052C2a
Isotype IgG1
Method of Purification ATF7IP antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer ATF7IP antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance ATF7IP is a recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9'. The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation.

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Images

  • Western Blot analysis of immunized recombinant protein using ATF7IP antibody (10R-1315) | Left: ATF7IP staining. Right: Coomassie Blue staining of immunized recombinant protein.

Availability: In stock

Price: $190.00
Size: 50 ug
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