ATM antibody (10R-1413)

Mouse monoclonal ATM antibody

Synonyms Monoclonal ATM antibody, Anti-ATM antibody, ATA antibody, TEL1 antibody, ATD antibody, ATE antibody, DKFZp781A0353 antibody, MGC74674 antibody, Ataxia telangiectasia mutated antibody, ATDC antibody, ATC antibody, AT1 antibody, TELO1 antibody
Specificity Human ATM
Cross Reactivity Human. Other species not studied
Applications Dot Blot
Immunogen ATM antibody was raised in mouse using recombinant Human Ataxia Telangiectasia Mutated (Includes Complementation Groups A, C And D) (Atm)

Images

Western Blot analysis of immunized recombinant protein using ATM antibody (10R-1413)

Left: ATM staining. Right: Coomassie Blue staining of immunized recombinant protein.

Specifications

Host Mouse
Clone 543C3a
Isotype IgG1
Method of Purification ATM antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer ATM antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations To be optimized by the end user.

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

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Images

  • Western Blot analysis of immunized recombinant protein using ATM antibody (10R-1413) | Left: ATM staining. Right: Coomassie Blue staining of immunized recombinant protein.

Availability: In stock

Price: $190.00
Size: 50 ug
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