ATM antibody (10R-8536)

Mouse monoclonal ATM antibody

Synonyms Monoclonal ATM antibody, Anti-ATM antibody, ATM antibody, ataxia telangiectasia mutated antibody, AT1 antibody, ATA antibody, Ataxia telangiectasia gene mutated in human beings antibody, ataxia-telangiectasia mutated antibody, ataxia telangiectasia mutated homolog antibody, ataxia telangiectasia mutated homolog (human) antibody, ataxia telangiectasia mutated (includes complementation groups A antibody, C and D) antibody, ataxia telangiectasia mutated protein antibody, ATC antibody, ATD antibody, atdc antibody, ATE antibody, ATM (ataxia telangiectasia mutated) antibody, A-T mutated antibody, AT mutated antibody, A-T mutated homolog antibody, BOS_14328 antibody, chunp9624 antibody, serine-protein kinase ATM antibody, serine/threonine-protein kinase ATM antibody, TEL1 antibody, TEL1 antibody, telomere maintenance 1 antibody, homolog antibody, TELO1 antibody, Xatm antibody
Cross Reactivity Human
Applications ELISA, IP, WB
Immunogen ATM antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-ATM 2841-3056 a.a.) as the immunogen

Images

Western Blot analysis using ATM antibody (10R-8536)

Specifications

Host Mouse
Clone 9A2
Isotype IgG2b kappa
Method of Purification ATM antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:2000, IP: 1 ul

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Ataxia telangiectasia (AT) is a rare neurodegenerative, autosomal recessive disorder characterized by chromosome instability, radiosensitivity, immunodeficiency and a predisposition for cancer. The ATR (ATM and Rad3-related) kinase and its downstream effector kinase, Chk1, are central regulators of the replication checkpoint. Loss of these checkpoint proteins causes replication fork collapse and chromosomal rearrangements. ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability.

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Images

  • Western Blot analysis using ATM antibody (10R-8536) |

Availability: In stock

Price: $295.00
Size: 100 ul
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