ATM antibody (70R-14321)

Affinity purified Rabbit polyclonal ATM antibody

Synonyms Polyclonal ATM antibody, Anti-ATM antibody, AT1 antibody, TELO1 antibody, TEL1 antibody, ATA antibody, Ataxia telangiectasia mutated antibody, ATE antibody, Phospho Ser1981 antibody, DKFZp781A0353 antibody, ATC antibody, MGC74674 antibody, ATD antibody, ATDC antibody
Applications WB
Immunogen ATM antibody was raised in Rabbit using a synthetic peptide corresponding to a sequence at the N-terminal of human ATM, different from the related rat and Rabbit sequences by two amino acids, as the immunogen

Images

Western blot analysis using ATM antibody (70R-14321)

Lane 1: Rat Testicle Tissue Lysate, Lane 2: U87 Cell Lysate, Lane 3: MCF-7 Cell Lysate

Specifications

Host Rabbit
Isotype IgG
Method of Purification ATM antibody was purified by affinity chromatography
Form & Buffer Supplied in lyophilized form

Usage & Assay Information

Usage Recommendations Optimal conditions to be determined by the end user

Storage & Safety

Storage Store at 4 deg C for short term storage. For long term storage aliquot and store at -20 deg C, avoid repeated freeze/thaw cycles.

General Information

Biological Significance The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

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Images

  • Western blot analysis using ATM antibody (70R-14321) | Lane 1: Rat Testicle Tissue Lysate, Lane 2: U87 Cell Lysate, Lane 3: MCF-7 Cell Lysate
  • Western blot analysis using ATM antibody (70R-14321) | Lane 1: HELA Cell Lysate, Lane 2: SMMC Cell Lysate, Lane 3: U87 Cell Lysate, ,Lane 4: A549 Cell Lysate Lane 5: MCF-7 Cell Lysate

Availability: In stock

Price: $270.00
Size: 100 ug
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