AURKB antibody (10R-2091)
Mouse monoclonal AURKB antibody
|Synonyms||Monoclonal AURKB antibody, Anti-AURKB antibody, aurkb antibody, STK5 antibody, STK12 antibody, aurkb-sv1 antibody, Aurora and Ipl1 like midbody associated protein 1 antibody, Serine/threonine-protein kinase 12 antibody, IPL1 antibody, AIM1 antibody, Aurora related kinase 2 antibody, Aurora 1 antibody, ARK2 antibody, AIM1 antibody, Serine/threonine protein kinase 12 antibody, Aurora kinase B antibody, AIK2 antibody, aurkb-sv2 antibody, Serine/theronine kinase 12 antibody, STK1 antibody, Aurora/IPL1 related kinase 2 antibody, Aurora-B antibody, AurB antibody, AURKB antibody|
|Immunogen||AURKB antibody was raised in Mouse using a purified recombinant fragment of AURKB expressed in E. coli as the immunogen.|
Western Blot analysis using AURKB antibody (10R-2091)
Western Blot showing AURKB antibody used against truncated AURKB recombinant protein (1) and SKN-SH cell lysate (2).
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells|
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