Aurora kinase A protein (His tag) (80R-1165)
Purified recombinant Human Aurora kinase A protein
|Synonyms||AURA protein, Serine/threonine-protein kinase 6 Aurora 2 protein, Serine/threonine-protein kinase 6 protein, ARK1 protein, BTAK protein, Serine/threonine kinase 15., aurora kinase A protein, AURKA protein, IAK protein, AIK protein, Aurora A protein, STK6 protein, STK15 protein, Aurora kinase A protein, Aurora-A protein|
Coomassie Blue stained SDS-PAGE of Aurora kinase A protein (His tag) (80R-1165)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-403 amino acids: MGSSHHHHHH SSGLVPRGSH MDRSKENCIS GPVKATAPVG GPKRVLVTQQ FPCQNPLPVN SGQAQRVLCP SNSSQRIPLQ AQKLVSSHKP VQNQKQKQLQ ATSVPHPVSR PLNNTQKSKQ PLPSAPENNP EEELASKQKN EESKKRQWAL EDFEIGRPLG KGKFGNVYLA REKQSKFILA LKVLFKAQLE KAGVEHQLRR EVEIQSHLRH PNILRLYGYF HDATRVYLIL EYAPLGTVYR ELQKLSKFDE QRTATYITEL ANALSYCHSK RVIHRDIKPE NLLLGSAGEL KIADFGWSVH APSSRRTTLC GTLDYLPPEM IEGRMHDEKV DLWSLGVLCY EFLVGKPPFE ANTYQETYKR ISRVEFTFPD FVTEGARDLI SRLLKHNPSQ RPMLREVLEH PWITANSSKP SNCQNKESAS KQS|
|Purity||> 95% pure|
|Molecular Weight||47.9 kDa (423aa)|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0 with 0.5mM DTT, 100mM NaCl, 0.1mM EDTA, and 0.1mM EGTA.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Aurora Kinase A is a member of a family of mitotic serine/threonine kinases. It is implicated with important processes during mitosis and meiosis whose proper function is integral for healthy cell proliferation. Aurora kinase A is highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also this protein plays a crucial role in tumourigenesis and is overexpressed in many kinds of cancers. Recombinant human Aurora-A fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.|
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