AXL antibody (10R-2051)
Mouse monoclonal AXL antibody
|Synonyms||Monoclonal AXL antibody, Anti-AXL antibody, AXL receptor tyrosine kinase antibody, JTK11 antibody, UFO antibody|
|Applications||ELISA, IF, WB|
|Immunogen||AXL antibody was raised in Mouse using purified recombinant extracellular fragment of human AXL fused with hIgGFc tag expressed in HEK293 cell line as the immunogen.|
Immunofluorescent staining using Western Blot analysis using AXL antibody (10R-2051) (AXL antibody)
Confocal immunofluorescence analysis of methanol-fixed HEK293 cells trasfected with AXL-hIgGFc using AXL antibody (green), showing cytoplasmic and membrane localization. Blue: DRAQ5 fluorescent DNA dye.
|Form & Buffer||Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.|
Usage & Assay Information
|Usage Recommendations||ELISA: 1:10,000, IF: 1:200-1:1000, WB: 1:500-1:2000|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||AXL is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified.|
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