Bcl2 protein (His tag) (80R-1136)

Purified recombinant Human Bcl2 protein

Synonyms 2 protein, B-cell protein, Bcl 2, Bcl 2 protein, Leukemia/lymphoma protein, Bcl-2 protein, C430015F12Rik protein, AW986256 protein, B-cell lymphoma protein 2 alpha protein, Bcl2 protein, Bcl-2 protein, B cell CLL/lymphoma 2 protein, B-cell lymphoma protein 2 alpha Apoptosis regulator Bcl 2 protein, Apoptosis regulator Bcl2 protein, Bcl2, D630044D05Rik protein, Oncogene B-cell leukemia 2., B cell leukemia/lymphoma 2 protein, Bcl-2, D830018M01Rik protein
Species Human
Protein Type Recombinant
Applications SDS-PAGE

Images

Coomassie Blue stained SDS-PAGE of Bcl2 protein (His tag) (80R-1136)

Figure annotation denotes ug of protein loaded and % gel used.

Specifications

Residues 1-211 amino acids: MGSSHHHHHH SSGLVPRGSH MAHAGRTGYD NREIVMKYIH YKLSQRGYEW DAGDVGAAPP GAAPAPGIFS SQPGHTPHPA ASRDPVARTS PLQTPAAPGA AAGPALSPVP PVVHLTLRQA GDDFSRRYRR DFAEMSSQLH LTPFTARGRF ATVVEELFRD GVNWGRIVAF FEFGGVMCVE SVNREMSPLV DNIALWMTEY LNRHLHTWIQ DNGGWDAFVE LYGPSMRPLF D
Expression System E.coli
Purity > 90% pure
Molecular Weight 25.4 kDa (231 aa), confirmed by MALDI-TOF.
Tag/Conjugate His tag
Form & Buffer Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 20% glycerol, and 2 mM DTT.
Concentration 0.5 mg/ml

Storage & Safety

Storage Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.

General Information

Biological Significance Bcl-2, also known as B-cell lymphoma protein 2 alpha, is an anti-apoptotic protein located primarily in the outer mitochondrial membrane that blocks the apoptotic death of some cells such as lymphocytes. BCL-2 is thought to regulate cell death by controlling the mitochondrial membrane permeability during apotosis. Bcl-2 exerts its anti-apoptotic function through inhibiting caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). The Bcl-2 gene has been related with a number of cancers, including melanoma, breast, prostate, and lung carcinomas, as well as schizophrenia and autoimmunity. Recombinant Bcl-2 protein was expressed in E. coli and purified by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.

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Images

  • Coomassie Blue stained SDS-PAGE of Bcl2 protein (His tag) (80R-1136) | Figure annotation denotes ug of protein loaded and % gel used.

Availability: In stock

Price: $340.00
Size: 100 ug
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