Bence Jones Kappa Light Chain protein (30C-CP8105 )

PurifiedHuman Bence Jones Kappa Light Chain protein

Synonyms Human Bence Jones Kappa Light Chain protein, Bence Jones Kappa Chain protein, Human Bence Jones Kappa Light Chain, Purified Human Kappa Light Chain, Human Kappa Light Chain protein
Species Human
Protein Type Native
Applications Control


Source Urine of a single donor containing Bence Jones kappa chains
Purity > 95% pure
Method of Purification Bence Jones Kappa Light Chain protein was purified by affinity chromatography
Form & Buffer Supplied in liquid form in PBS buffer containing 0.1% sodium azide
Concentration 1 mg/ml

Usage & Assay Information

Usage Recommendations Optimal working dilutions should be determinedexperimentally by the investigator. Prepare working dilution immediately before use.

Storage & Safety

Storage Store at 2-8 deg C
Biohazard Information Serum or plasma from donor has been tested and found negative for HIV1 antigen, antibodies for HIVand HCV, and non-reactive for HBsAg, HIV1 RNA, and HCV RNA. It was not tested for Anti-HBc.

General Information

Biological Significance Bence Jones Kappa proteinsare immunoglobulin light chains (paraproteins) and are produced by neoplastic plasma cells. They can be kappa (most of the time) or lambda. The light chains can be immunoglobulin fragments or single homogeneous immunoglobulins. They are found in urine due to the kidneys' decreased filtration capabilities due to renal failure, sometimes induced by hypercalcemia from the calcium released as the bones are destroyed or from the light chains themselves. The light chains have historically been detected by heating and now by electrophoresis of concentrated urine. The kappa chain is encoded by the immunoglobulin kappa locus on chromosome 2. Human Bence Jones kappa chain are routinely used as a positive control in immunoassays.

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Availability: In stock

Price: $195.00
Size: 1 mg
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