beta Amyloid protein (30R-3244)

Purified recombinant beta Amyloid protein

Synonyms ABPP protein, APPI protein, APP protein, Alzheimer disease amyloid protein, Cerebral vascular amyloid peptide protein, CVAP protein, PreA4 Protease nexin II protein, PN II protein, Amyloid beta A4 protein
Species Human
Protein Type Recombinant
Applications ELISA, SDS-PAGE, WB

Specifications

Expression System E.coli
Purity > 90% pure
Molecular Weight 78 kDa
Form & Buffer Supplied in liquid form in 6M guanidine hydrochloride and 20mM Tris buffer

Storage & Safety

Storage Store at 4 deg C in a working aliquot for 1 week. For long term storage, aliquot and freeze at -20 to -80 deg C, avoid repeat freeze/thaw cycles

General Information

Biological Significance beta Amyloid functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. beta Amyloid acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu2+-mediated low-density lipoprotein oxidation.

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Availability: In stock

Price: $210.00
Size: 50 ug
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