BFIT protein (His tag) (80R-3569)
Purified recombinant BFIT protein (His tag)
|Synonyms||Acyl-CoA thioester hydrolase 11 protein, Acyl-CoA thioesterase 11 protein, Acyl-coenzyme A thioesterase 11 protein, Adipose-associated thioesterase protein, Brown fat-inducible thioesterase protein, KIAA0707 protein, THEA protein|
Coomassie blue stained SDS-PAGE of BFIT protein (His tag) (80R-3569)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||19-250 aa: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSNRTS RKSALRAGND SAMADGEGYR NPTEVQMSQL VLPCHTNQRG ELSVGQLLKW IDTTACLSAE RHAGCPCVTA SMDDIYFEHT ISVGQVVNIK AKVNRAFNSS MEVGIQVASE DLCSEKQWNV CKALATFVAR REITKVKLKQ ITPRTEEEKM EHSVAAERRR MRLVYADTIK DLLANCAIQG DLESRDCSRM VPAEKTRVES VELVLPPHAN HQGNTFGGQI MAWMENVA|
|Purity||> 90% pure|
|Method of Purification||BFIT protein was purified by using conventional chromatography techniques|
|Molecular Weight||29.9 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.4M Urea,10% glycerol|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||BFIT is a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. The protein has acyl-CoA thioesterase activity towards medium (C12) and long-chain (C18) fatty acyl-CoA substrates.|
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