Bid antibody (10R-8491)

Mouse monoclonal Bid antibody

Synonyms Monoclonal Bid antibody, Anti-Bid antibody, BID antibody, BH3 interacting domain death agonist antibody, apoptic death agonist antibody, apoptotic death agonist BID antibody, BH3-interacting domain death agonist antibody, BID isoform ES(1b) antibody, BID isoform L(2) antibody, BID isoform Si6 antibody, BOS_6089 antibody, desmocollin type 4 antibody, FP497 antibody, Human BID coding sequence antibody, p22 BID antibody, RCJMB04_7d15 antibody, xbid antibody
Cross Reactivity Human
Applications WB
Immunogen Bid antibody was raised in Mouse using a recombinant human protein purified from E.coli(His-Bid) as the immunogen

Images

Western Blot analysis using Bid antibody (10R-8491)

Specifications

Host Mouse
Clone 21F10
Isotype IgG2a kappa
Method of Purification Bid antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1 :10000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Bid consists of only one Bcl-2 homology domain, BH3. Bid cleavage to tBid (truncated Bid) activates apoptotic pathway at the mitochondrial level. Cleavage of cytosolic Bid and subsequent mitochondrial translocation have been detected in neuronal cell death related to acute or chronic neurodegeneration. Pharmacological inhibition of Bid can be a promising therapeutic strategy in neurological diseases where programmed cell death is prominent. After Bid activation and mitochondrial translocation, the most prominent downstream mechanisms of Bid-dependent neuronal apoptosis involve disruption of mitochondrial membrane integrity and intracellular calcium homoeostasis and the release of pro-apoptotic mitochondrial factors such as cytochrome c.

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Images

  • Western Blot analysis using Bid antibody (10R-8491) |

Availability: In stock

Price: $295.00
Size: 100 ul
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