BID protein (30R-1173)
Purified recombinant Human BID protein
|Synonyms||p22 BID., p13 BID protein, Apoptotic death agonist BID protein, BH3 interacting domain death agonist isoform 2 Apoptotic death agonist protein, Human BID coding sequence protein, BH3 interacting domain death agonist p11 protein, MGC42355 protein, p11 BID protein, BID isoform L(2) protein, OTTHUMP00000196197 protein, BH3 interacting domain death agonist p13 protein, MGC15319 protein, HGNC:1050 protein, BID protein, BH3 interacting domain death agonist protein, BID isoform ES(1b) protein, p15 BID protein, BH3 interacting domain death agonist p15 protein, BH3 interacting domain death agonist isoform 2 protein, Desmocollin type 4 protein, FP497 protein|
Coomassie Blue stained SDS-PAGE of BID protein (30R-1173)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-195 amino acids: MDCEVNNGSS LRDECITNLL VFGFLQSCSD NSFRRELDAL GHELPVLAPQ WEGYDELQTD GNRSSHSRLG RIEADSESQE DIIRNIARHL AQVGDSMDRS IPPGLVNGLA LQLRNTSRSE EDRNRDLATA LEQLLQAYPR DMEKEKTMLV LALLLAKKVA SHTPSLLRDV FHTTVNFINQ NLRTYVRSLA RNGMD|
|Purity||> 95% pure|
|Molecular Weight||21.9 kDa (195 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl, pH 8.0, containing 20% glycerol.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||BID is a pro-apoptotic Bcl-2 protein containing only the BH3 domain. In response to apoptotic signaling, BID interacts with another Bcl-2 family protein, Bax, leading to the insertion of Bax into the outer mitochondrial membrane. Bax is believed to induce the opening of the mitochondrial voltage-dependent anion channel. This results in the release of cytochrome c and other pro-apoptotic factors from the mitochondria leading to activation of caspases. Recombinant BID protein was expressed in E. coli and purified by using conventional chromatography techniques.|
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