BIGH3 protein (30R-1079)
Purified recombinant Human BIGH3 protein
|Synonyms||CSD1 protein, beta induced protein, Beta ig h3 protein, CDB1 protein, TGFBI protein, BIGH -3 protein, CSD protein, AI747162 protein, LCD1 protein, Fasciclin domain 4 protein, RGD CAP protein, BIGH3 protein, RGD-CAP protein, BIGH3, EBMD protein, CSD2 protein, CSD3 protein, AI181842 protein, TGFBI transforming growth factor protein, RGD containing collagen associated protein protein, BIGH -3, Kerato epithelin protein, CDG2 protein, Beta ig-h3 protein, big h3 protein, CDGG1 protein, Beta ig protein, BIGH 3, Transforming growth factor-beta-induced protein ig-h3 protein, MGC150270 protein, Transforming growth factor beta induced protein ig h3., RGD-containing collagen-associated protein protein, Kerato-epithelin protein, BIGH 3 protein, 68kDa protein, BIGH3 protein|
Coomassie Blue stained SDS-PAGE of BIGH3 protein (30R-1079)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||Fasciclin domain 4502-636 amino acids: MGTVMDVLKG DNRFSMLVAA IQSAGLTETL NREGVYTVFA PTNEAFRALP PRERSRLLGD AKELANILKY HIGDEILVSG GIGALVRLKS LQGDKLEVSL KNNVVSVNKE PVAEPDIMAT NGVVHVITNV LQPPA|
|Purity||> 95% pure|
|Molecular Weight||14.5 kDa (135 aa), confirmed by MALDI-TOF.|
|Form & Buffer||Supplied as a liquid in 20mM Tris, pH 8.0.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||BIGH3, also known as TGFBI and betaig-h3, is an extracellular matrix protein induced by transforming growth factor(TGF)-beta 1. BIGH3 protein is involved in cell growth, cell differentiation, wound healing and cell adhesion. In addition, some missense mutations of BIGH3 were identified in families affected with human autosomal dominant corneal dystrophies. BIGH3 gene encodes for a 683 amino-acid protein containing an RGD motif and four internal repeated domains which have highly conserved sequences founded in several species (Fasciclin domain). Recombinant human BIGH3 protein (fourth FAS domain) was expressed in E. coli and purified by using conventional chromatography techniques.|
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