BMI1 antibody (10R-8131)

Mouse monoclonal BMI1 antibody

Synonyms Monoclonal BMI1 antibody, anti-BMI1 antibody, BMI-1 antibody, BMI 1 antibody, BMI1
Cross Reactivity Human, Mouse, Rabbit, Rat
Applications IHC-F, IP, WB
Immunogen BMI1 antibody was raised in Mouse using recombinant Bmi1 protein corresponding to residues 1-202 of mouse Bmi-1 acterial fusion protein of membrane proximal non repeat domain of human episialin as the immunogen.

Specifications

Host Mouse
Clone 229F6
Isotype IgG1
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations Optimal dilution should be determined by titration

General Information

Biological Significance BMI1 polycomb ring finger oncogene, also known as BMI1, is a protein which in humans is encoded by the BMI1 gene. BMI1 (B lymphoma Mo-MLV insertion region 1 homolog) has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 is rapidly recruited to sites of DNA damage and it sustains for over than 8h. Loss of BMI1 leads to radiation sensitive and impaired repair of DNA double-strand breaks by homologous recombination. Bmi1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells.

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Availability: In stock

Price: $395.00
Size: 100 ug
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