Brutons tyrosine kinase antibody (10R-8474)

Mouse monoclonal Brutons tyrosine kinase antibody

Synonyms Monoclonal Brutons tyrosine kinase antibody, Anti-Brutons tyrosine kinase antibody, BTK antibody, Bruton's tyrosine kinase antibody, Bruton agammaglobulinemia tyrosine kinase antibody, agammaglobulinaemia tyrosine kinase antibody, AGMX1 antibody, AT antibody, atk antibody, B-cell progenitor kinase antibody, BOS_25575 antibody, bpk antibody, Brutons tyrosine kinase antibody, bruton tyrosine kinase antibody, dominant-negative kinase-deficient Brutons tyrosine kinase antibody, imd1 antibody, kinase EMB antibody, psctk1 antibody, RCJMB04_6h8 antibody, RP1-164F3.2 antibody, RP23-91G19.5 antibody, tyrosine-protein kinase BTK antibody, Tyrosine-protein kinase BTK (Brutons tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B cell progenitor kinase) (BPK) (Kinase EMB) antibody, tyrosine-protein kinase BTK isoform (lacking exon 14) antibody, xid antibody, XLA antibody, X-linked immune deficiency antibody
Cross Reactivity Human
Applications ELISA, IHC-P, WB
Immunogen Brutons tyrosine kinase antibody was raised in Mouse using a recombinant human protein purified from E.coli (His/ABD-Btk) as the immunogen

Images

Western Blot analysis using Bruton's tyrosine kinase antibody (10R-8474)

Specifications

Host Mouse
Clone 1A1
Isotype IgG1 kappa
Method of Purification Brutons tyrosine kinase antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:5000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Btk (Brutons tyrosine kinase) is a member of the Tec family of protein tyrosine kinases (PTKs) and plays a modulatory role in many cellular processes, such as proliferation, development, differentiation, survival, and apoptosis. The Tec kinases are the second largest family of non-receptor tyrosine kinases and include Tec, Btk, Bmx, Itk, and TXK/Rlk. Mutations of Btk gene cause a primary immunodeficiency disease in humans, X-linked agammaglobulinemia (XLA) which is characterized by a lack of circulating B lymphocytes and an absence of immunoglobulins as a result of defects in B cell maturation and function. Btk is found in all hematopoietic cells, with the exception of T lymphocytes and plasma cells. Btk contains amino-terminal PH (pleckstrin homology) domain which binds phosphatidylinositol (3,4,5)-trisphosphate (PIP3) helping membrane translocation upon PI3 kinase activation.

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Images

  • Western Blot analysis using Bruton's tyrosine kinase antibody (10R-8474) |

Availability: In stock

Price: $295.00
Size: 100 ul
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