CAB39L protein (His tag) (80R-2630)
Purified recombinant Human CAB39L protein (His tag)
|Synonyms||CABL-39 protein, MO25-BETA protein, MO2L protein, CAB39L, Calcium-binding protein 39-like protein, CABL 39 protein, CABL-39, CABL 39|
SDS-PAGE analysis of CAB39L protein (His tag) (80R-2630)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-337 aa: MGSSHHHHHH SSGLVPRGSH MGSMKKMPLF SKSHKNPAEI VKILKDNLAI LEKQDKKTDK ASEEVSKSLQ AMKEILCGTN EKEPPTEAVA QLAQELYSSG LLVTLIADLQ LIDFEGKKDV TQIFNNILRR QIGTRSPTVE YISAHPHILF MLLKGYEAPQ IALRCGIMLR ECIRHEPLAK IILFSNQFRD FFKYVELSTF DIASDAFATF KDLLTRHKVL VADFLEQNYD TIFEDYEKLL QSENYVTKRQ SLKLLGELIL DRHNFAIMTK YISKPENLKL MMNLLRDKSP NIQFEAFHVF KVFVASPHKT QPIVEILLKN QPKLIEFLSS FQKERTDDEQ FADEKNYLIK QIRDLKKTAP|
|Method of Purification||CAB39L protein was purified using Protein G affinity chromatography|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH 8.0) containing 0.1M NaCl, 10% glycerol, 1mM DTT|
Storage & Safety
|Storage||Store at 4 deg C for short term storage. Aliquot and store at -20 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||Calcium-binding protein 39-like, also known as CAB39L, is similar to MO25 and is found in the serum of nearly half of all patients diagnosed with acute monocytic leukemia. This protein suggests a role for CAB39L in carcinogenesis. Also, LKB1 activity increases upon the binding of a regulatory complex consisting of the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase and the CAB39L. Recombinant human CAB39L protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.|
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