CACYBP protein (His tag) (80R-1330)
Purified recombinant Human CACYBP protein
|Synonyms||S100A6BP protein, GIG5 protein, Growth inhibiting gene 5 protein protein, PNAS 107 protein, PNAS-107 protein, S100A6 binding protein., MGC87971 protein, SIP protein, RP1 102G20.6 protein, Calcyclin binding protein protein, Clcyclin-binding protein CACYBP protein, GIG 5 protein, RP1-102G20.6 protein, PNAS107 protein, hCacyBP protein, Growth inhibiting gene 5 protein|
Coomassie Blue stained SDS-PAGE of CACYBP protein (His tag) (80R-1330)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||1-185 amino acids: MGSSHHHHHH SSGLVPRGSH MQQKSQKKAE LLDNEKPAAV VAPITTGYTV KISNYGWDQS DKFVKIYITL TGVHQVPTEN VQVHFTERSF DLLVKNLNGK SYSMIVNNLL KPISVEGSSK KVKTDTVLIL CRKKVENTRW DYLTQVEKEC KEKEKPSYDT ETDPSEGLMN VLKKIYEDGD DDMKRTINKA WVESREKQAK GDTEF|
|Purity||> 85% pure|
|Molecular Weight||23.4 kDa (205aa), confirmed by MALDI-TOF|
|Form & Buffer||Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 10% glycerol, 1mM DTT and 0.1M NaCl.|
Storage & Safety
|Storage||Store at 4 deg C for short term storage (1/2 weeks). Aliquot and store at -20 deg C or - 70 deg C for long term storage. Avoid repeated freeze/thaw cycles.|
|Biological Significance||CACYBP is primarily a nuclear protein that contains one CS domain and one SGS domain. It is believed to be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It most likely serves as a molecular bridge in Ubiquitin E3 complexes. It also participates in the Ubiquitin-mediated degradation of beta-catenin. CACYBP is thought to be a potential inhibitor of cell growth and invasion in the gastric cancer cell through its effects on beta-catenin protein expression and transcriptional activation of TCF/LEF. Recombinant human CACYBP protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.|
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