Cardiotin antibody (10R-7954)

Mouse monoclonal Cardiotin antibody

Synonyms Monoclonal Cardiotin antibody, Anti-Cardiotin antibody, Cardiotin
Specificity Reacts with cardiotin, a mitochondrion-associated protein, which is present in cardiomyocytes and skeletal muscle
Cross Reactivity Canine, Feline, Goat, Hamster, Human, Monkey, Mouse, Rabbit, Rat, Xenopus, Zebrafish
Applications IHC-F, IHC-P, WB
Immunogen Cardiotin antibody was raised in Mouse using a total protein extract of chicken gizzard as the immunogen.

Specifications

Host Mouse
Clone R2G
Isotype IgM
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations IHC: 1:25-1:100

General Information

Biological Significance Cardiotin is a high molecular weight protein complex (300 kDa) located in the mitochondria of cardiomyocytes and skeletal muscle. The cardiotin structure exists of subunits of 60 kDa and 100 kDa, probably in a tetrameric configuration. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to human skeletal muscle alpha-actinin. During cardiac contractile dysfunction and myocard cell differentiation, the cardiotin distribution is affected. Compared to other structural proteins, cardiotin is one of the first to respond to insults (ischemia, fibrillation) that influence the functional status of cardiomyocytes.

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Availability: In stock

Price: $360.00
Size: 100 ug
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