Cardiotin antibody (10R-7955)

Mouse monoclonal Cardiotin antibody

Synonyms Monoclonal Cardiotin antibody, Anti-Cardiotin antibody, Cardiotin
Specificity Recognizes cardiomyocytes, skeletal muscle, stromal and epithelial cells as well in vivo as in vitro
Cross Reactivity Human, Swine
Applications IHC-F, IHC-P, WB
Immunogen Cardiotin antibody was raised in Mouse using the 100 kDa cardiotin subunit as the immunogen.

Specifications

Host Mouse
Clone SR-2
Isotype IgM
Form & Buffer Supplied in PBS containing 0.09% sodium azide

Usage & Assay Information

Usage Recommendations IHC: 1:25-1:100, WB: 1:50-1:500

General Information

Biological Significance Cardiotin is a high molecular weight protein complex (300 kDa) located in the mitochondrial membrane. The cardiotin structure exists as subunits of 60 kDa and 100 kDa. Both subunits contain the same amino-terminal 14 amino-acid sequence, showing high homology to human skeletal muscle a-actinin, suggesting that the tetrameric configuration of the cardiotin protein structure is a transmembrane complex with the N-terminus at the cytoplasmic side of the membrane, able to interact with actin. During cardiac contractile dysfunction, the cardiotin distribution is affected in pathlogical cardiomyocytes i.e. chronic ischemic myocardium.

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Availability: In stock

Price: $360.00
Size: 100 ug
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