Cathepsin D antibody (10R-8600)

Mouse monoclonal Cathepsin D antibody

Synonyms Monoclonal Cathepsin D antibody, Anti-Cathepsin D antibody, CTSD antibody, cathepsin D antibody, BOS_25072 antibody, catD antibody, cathepsin D (lysosomal aspartyl peptidase) antibody, cathepsin D (lysosomal aspartyl protease) antibody, cathepsin D preproprotein antibody, CD antibody, ceroid-lipofuscinosis antibody, neuronal 10 antibody, CLN10 antibody, CPSD antibody, DKEY-207D5.3 antibody, etID16901.18 antibody, fb93e11 antibody, fj17b09 antibody, lysosomal aspartyl peptidase antibody, lysosomal aspartyl protease antibody, prepro-cathepsin D antibody, prepro-CD antibody
Cross Reactivity Human
Applications WB
Immunogen Cathepsin D antibody was raised in Mouse using a recombinant human protein purified from E.coli (His-Cathepsin D) as the immunogen

Images

Western Blot analysis using Cathepsin D antibody (10R-8600)

Specifications

Host Mouse
Clone AF1C7
Isotype IgG1 kappa
Method of Purification Cathepsin D antibody was purified by ammonium sulfate precipitation
Form & Buffer Supplied in liquid form in HEPES buffer with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol

Usage & Assay Information

Usage Recommendations WB: 1:5000

Storage & Safety

Storage Aliquot and store for 1 year at -20 deg C, avoid freeze/thaw cycles

General Information

Biological Significance Cathepsin D (CatD) is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins apoptosis and autophagy. Human CatD is synthesized on the endoplasmic reticulum as a pre-pro-enzyme. Preprocathepsin D (412aa) is cleaved and glycosylatedto form an inactive procathepsin D (392aa) and then further cleaved to generate an active intermediate (348aa) single-chain molecule. The active intermediate is further processed into mature two chain form of cathepsin D, this processing step is carried out by cathepsin B or L. The two-chain form consists of an amino terminal light chain and a carboxyl-terminal heavy chain. Additionally, several more amino acids are removed from the carboxyl terminus of the heavy chain.

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Images

  • Western Blot analysis using Cathepsin D antibody (10R-8600) |

Availability: In stock

Price: $295.00
Size: 100 ul
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