CBL antibody (10R-1404)

Mouse monoclonal CBL antibody

Synonyms Monoclonal CBL antibody, Anti-CBL antibody, CBL2 antibody, Cas-Br-M (murine) ecotropic retroviral transforming sequence antibody, C-CBL antibody, RNF55 antibody
Specificity Human CBL
Cross Reactivity Human. Other species not studied
Applications Dot Blot, ICC, WB
Immunogen CBL antibody was raised in mouse using recombinant Human Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (Cbl)

Images

Immunofluorescent staining using CBL antibody (10R-1404)

Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CBL antibody.

Specifications

Host Mouse
Clone 2111C3a
Isotype IgG1
Method of Purification CBL antibody was purified using protein G column chromatography from culture supernatant of hybridoma cultured in a medium containing bovine IgG-depleted (approximately 95%) fetal bovine serum.
Form & Buffer CBL antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1% bovine serum albumin (BSA) and 0.05% sodium azide (NaN3 ).
Concentration 100 ug/ml

Usage & Assay Information

Usage Recommendations WB: 0.2-2 ug/ml

Storage & Safety

Storage Store at 2-8 deg C for up to one year. We recommend long term storage at -20 deg C. Avoid repeated freezing and thawing.
Biohazard Information This antibody solution contains sodium azide (NaN ) as a preservative. There is a potential hazard that NaN reacts with copper or lead to produce an explosive compound. For safe disposal, the vial has to be washed thoroughly with water. It is strongly adv

General Information

Biological Significance The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.

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Images

  • Immunofluorescent staining using CBL antibody (10R-1404) | Immunostaining analysis in HeLa cells. HeLa cells were fixed with 4% paraformaldehyde and permeabilized with 0.01% Triton-X100 in PBS. The cells were immunostained with anti-CBL antibody.
  • Western Blot analysis of immunized recombinant protein using CBL antibody (10R-1404)

Availability: In stock

Price: $190.00
Size: 50 ug
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