CCM2 protein (His tag) (80R-3629)
Purified recombinant CCM2 protein (His tag)
|Synonyms||Malcavernin isoform 4 protein, CCM 2 protein, CCM-2 protein|
Coomassie blue stained SDS-PAGE of CCM2 protein (His tag) (80R-3629)
Figure annotation denotes ug of protein loaded and % gel used.
|Residues||66-353 aa: MGSSHHHHHH SSGLVPRGSH MGSEVKYLGQ LTSIPGYLNP SSRTEILHFI DNAKRAHQLP GHLTQEHDAV LSLSAYNVKL AWRDGEDIIL RVPIHDIAAV SYVRDDAAHL VVLKTDDSST KVDIKETYEV EASTFCFPES VDVGGASPHS KTISESELSA SATELLQDYM LTLRTKLSSQ EIQQFAALLH EYRNGASIHE FCINLRQLYG DSRKFLLLGL RPFIPEKDSQ HFENFLETIG VKDGRGIITD SFGRHRRALS TTSSSTTNGN RATGSSDDRS APSEGDEWDR MISDISSDIE ALGCSMDQDS A|
|Purity||> 90% pure|
|Method of Purification||CCM2 protein was purified by using conventional chromatography techniques|
|Molecular Weight||34.3 kDa|
|Form & Buffer||Supplied in liquid form in 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol 1mM DTT|
Storage & Safety
|Storage||Can be stored at 4 deg C short term (1-2 weeks). For long term storage, aliquot and store at -20 deg C or -70 deg C. Avoid repeated freezing and thawing cycles.|
|Biological Significance||CCM2 provides instructions for making a protein called malcavernin, which strengthens the interactions between cells that form blood vessels and limits leakage from the vessels. It interacts with a number of other proteins to form a complex that is found in the junctions that connect neighboring cells. It helps turn off (suppress) a signaling molecule known as RhoA-GTPase.|
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